Ariadne Labs formed the United States (U.S.) Coalition for Early T1D Action in 2025 to develop a practical, evidence-informed clinical pathway for T1D autoantibody screening and follow-up care. Launched in 2025, the coalition brought together 25 clinicians, researchers, health system leaders, and patient and family representatives from across the U.S.
The coalition’s key goals were to:
- Co-design a core clinical pathway for pediatric T1D screening and monitoring that could be adapted for diverse primary care settings.
- Develop the guidance and resources needed for real-world implementation.
- Plan for testing, refinement, and scale-up of the pathway and tools over time.
In 2025 and 2026, Ariadne Labs led a series of in-person convenings and virtual activities to co-design solutions with Coalition members and inform ongoing efforts to iterate on prototypes. In partnership with the Coalition, Ariadne Labs released the 2025 Landscape Report Update along with the SPOT T1D-Kids Clinical Pathway and Tools and supporting implementation guide.
Implementation science and quality improvement (QI) methods guided this work. The guidance and resources are aligned with evidence-based frameworks such as EPIS, CFIR, RE-AIM, and the Model for Improvement to systematically guide sites in planning for addressing barriers, identifying facilitators, and guiding context-specific adaptations.
The Coalition also developed an initial plan for testing and spreading the pathway that is responsive to the types of evidence needed by health system leaders, payers, and guideline developers.
Coalition Members include:
- Sungeeta Agrawal
Advocate Health/Wake Forest School of Medicine - Lisa B. Brown, MD, FAAP
- Colleen Buggs-Saxton, MD, PhD
Wayne State University School of Medicine, Wayne Pediatrics - Carla Demeterco-Berggren, MD, PhD
University of California, San Diego / Rady Children’s Hospital, San Diego - Daniel DeSalvo, MD
Baylor College of Medicine / Texas Children’s Hospital - Kurt J. Griffin, PhD, MD
Benaroya Research Institute - Franklin Hickey, PhD, RN, NEA-BC
University Hospital, Newark, NJ - Kathryn Hilde, PhD
Caregiver - Benjamin A. Kruskal, MD, PhD, FAAP, FIDSA
Blue Cross Blue Shield of Massachusetts - Julianne Lally, DMSc, MHS, PA-C
Breakthrough T1D - Ryan Lester, MPH, MBA
- Marissa R. Lorenzetti, MPA
Caregiver
- Martha Middlemist, MD, FAAP
Pediatrics 5280 - Kate Millington, MD
Hasbro Children’s Brown University Health - Kit Nichols
Caregiver - Lyn Nuse, MD
Atrium Health - Marian Rewers, MD, PhD
Barbara Davis Center for Diabetes, School of Medicine, University of Colorado - Anna Sabino, MSW, CDCES
Integrated Diabetes Services and Finding Smiles Coaching - Rebecca Schneider Aguirre, MD, PhD
Baylor College of Medicine - Alisa Seo-Lee, MD
Cook County Health - Denton Shanks, DO, MPH
American Academy of Family Physicians, The University of Kansas Health System - Marlena Sherman, DNP, MPH, APRN, CPNP-PC
- Margaret Zylstra
Patient Advisor