The LIFT-UP Project: Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package

LIFT-UP aims to close a critical know-do gap: there are feeding practices and supportive care interventions that we know can help small vulnerable newborns survive and thrive, but they don’t reach all who can benefit.

LIFT-UP is a group of studies investigating ways to improve feeding and growth of small vulnerable newborns (SVNs) in low-resource settings. These infants — born preterm, small for their gestational age or a combination of the two — account for 55.3% of global neonatal deaths. 

Although there are concrete steps clinicians, mothers, and families can take to care for these infants, proven interventions don’t reach all who need them. (source)

LIFT-UP includes two main components:

  • A comprehensive support and counseling package that LIFT-UP co-designed, implemented and evaluated to improve practices in lactation, mother’s own milk feeding, Kangaroo Mother Care, and safe hygiene in India, Tanzania, and Malawi (2025 – 2026).
  • A human milk fortification randomized control trial to explore the efficacy of human milk fortification for very low birthweight and/or very preterm infants on growth and morbidity outcomes in India (2025 – 2027).

Building a Global Good

Beyond strengthening the evidence base, LIFT-UP is creating a global good. 

The Feeding Support Package Plus (FSP+) was co-designed with the people who ultimately use its tools — government and facility leadership, clinicians and community providers, mothers and families — and evaluated through implementation science research to ensure it is practical in the real world. 

The FSP+ is freely available to download, use, and adapt so facility leadership and managers as well as policymakers around the world can put it to work in their own settings. 

LIFT-UP Consortium Partners

  • Ariadne Labs, United States
  • Community Empowerment Lab, India
  • Jawaharlal Nehru Medical College, Belgaum, India
  • University of North Carolina–Project Malawi, Lilongwe, Malawi
  • Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
  • Emory University, Atlanta, GA
  • Brigham and Women’s Hospital, Boston, MA
  • Boston Children’s Hospital, Boston, MA
  • Harvard T.H. Chan School of Public Health, Boston, MA
  • The Warren Alpert Medical School of Brown University, Providence, RI
  • PATH, Seattle, WA